Monitoring and Detecting Lupus Nephritis Through Urinary Extracellular Vesicles in Urine
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that can lead to irreversible kidney damage if not detected and managed promptly. LN is classified and treated based on its histopathological features obtained by invasive kidney biopsy. Recent research has suggested urinary extracellular vesicles (uEVs) as potential non-invasive biomarkers. The primary objective of this prospective study is to investigate the utility of uEVs in LN.
• \> 18 years old
• Fulfilling the 2019 EULAR/ACR classification criteria
• Positive autoantibodies, medical history and obejctive examination compatible with SLE
• Referred to kidney biopsy
• \> 18 years old
• Fulfilling the 2019 EULAR/ACR classification criteria
• Positive autoantibodies, medical history and obejctive examination compatible with SLE
• Normal plasma creatinine
• Urine albumine/creatinine \< 100 mg/g
• \> 18 years old
• No known kidney disease
• \> 18 years old
• Negative autoantibiodies and immunoglobulines
• Referred to kidney biopsy