Mononeuritis Multiplex Clinical Trials

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Efficacy of Combining Ultrasound-Guided Needle Release of Transverse Carpal Ligament and Median Nerve Dextrose Water Hydrodissection for Carpal Tunnel Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Carpal tunnel syndrome (CTS) is a common musculoskeletal disorder, which is caused by compression of the median nerve as it travels through the wrist. There are several treatments for CTS, including conservative and surgical options. Though local corticosteroid injection has been considered more effective than physical therapy for treatment of CTS and has significant short-term benefits, long term benefits are not evidenced. Several studies in recent years reported significantly superior longer-term benefit of D5W and PRP compared with corticosteroid injections and other conservative managements. In addition, percutaneous release of the transverse carpal ligament (TCL) was developed to treat CTS in recent years. Because the effectiveness of the recently developed techniques in treating CTS has not been well established, the investigators aim to investigate whether combining US-guided partial release of the transverse carpal ligament with a needle plus D5W hydrodissection is more beneficial for CTS comparing to either treatment alone.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 80
Healthy Volunteers: f
View:

• age between 20 to 80 years old

• diagnosed with CTS on the basis of clinical condition and an electrophysiological analysis

• the NRS of pain or paresthesia≧3

• with symptoms lasting for a minimum of 3 months.

Locations
Other Locations
Taiwan
Shin Kong Wu Ho-Su Memorial Hospital
RECRUITING
Taipei
Contact Information
Primary
Lin-Fen Hsieh
M001026@ms.skh.org.tw
+886-28332211
Time Frame
Start Date: 2026-01-01
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 102
Treatments
Active_comparator: US-guided D5W perineural hydrodissection alone, group A
Patients in the group A will receive 1 session of ultrasound-guided perineural injection with 5ml D5W.
Active_comparator: US guided partial release of the TCL with a needle + D5W injection (to TCL), group B
Patients in the group B will receive 1 session of ultrasound-guided partial release of the TCL with a needle plus D5W injection to TCL.
Active_comparator: US-guided partial release of the TCL with D5W injection to TCL plus D5W perineural hydrodissection
Patients in the group C will receive 1 session of the treatment combining group A and group B.
Sponsors
Leads: Shin Kong Wu Ho-Su Memorial Hospital

This content was sourced from clinicaltrials.gov