A Clinical Study to Gather Data on the Utility of Tests That Are Used to Make a Diagnosis of Primary Ciliary Dyskinesia (PCD)

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

This cross-sectional and longitudinal observational study is to gather data on the utility of tests that are used to make a diagnosis of primary ciliary dyskinesia (PCD). There is new testing available, called nasal nitric oxide testing, that non-invasively measures nitric oxide levels in the sinus cavity. Individuals with PCD characteristically have low levels, but this testing does not have extensive data from everyday clinical practice. The objective of this proposal is to improve the diagnostic approach to children and adults with clinical concerns for primary ciliary dyskinesia (PCD).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 2
Healthy Volunteers: f
View:

• Age ≥ 2 years of age

• Must have two of the following clinical history points:

• Neonatal respiratory distress

• Chronic nasal congestion/runny nose

• Chronic cough

• Situs/laterality defects

• Bronchiectasis

• Ability to provide informed consent or consent of parent/guardian and ass

Locations
United States
Connecticut
Pulmonary Division
RECRUITING
Hartford
Contact Information
Primary
Melanie S Collins, MD
mcollin@connecticutchildrens.org
860-545-9440
Backup
Sigrid M Almeida, BS
salmeida@connecticutchildrens.org
8608375343
Time Frame
Start Date: 2023-10-17
Estimated Completion Date: 2028-12
Participants
Target number of participants: 50
Treatments
Nasal Nitric Oxide
Participants who are referred by his/her clinician for nasal NO testing and meet the inclusion and exclusion criteria will undergo testing. Clinical information regarding prior diagnostic testing will be collected at time of enrollment. Participants that have a confirmed diagnosis of PCD by genetics or ciliary biopsy at time of study entry
Sponsors
Collaborators: UConn Health
Leads: Connecticut Children's Medical Center

This content was sourced from clinicaltrials.gov