A Cross-Sectional and Open Pre-Post Interventional Study Evaluating Circulating and Mucosal Humoral and Cell-Mediated Immunity Following Measles, Mumps and Rubella (MMR) Vaccination in Adults
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to investigate the immunity of persons fully vaccinated against measles, mumps and rubella and to examine the course of immunity after booster vaccination.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 49
Healthy Volunteers: t
View:
• Aged 18-49 (inclusive) at the time of the study screening visit
• Has received exactly two previous doses of MMR-containing vaccine at any point up to one calendar year prior to the study screening visit
• Willing to receive a booster MMR vaccination as outlined in the study protocol
• Able and willing to comply with all other study requirements (attend all study visits and provide blood, saliva, nasal wash samples at each visit as outlined)
• Sufficient language (German or English) and cognitive skills
• Provides written, informed consent to participate in the study
Locations
Other Locations
Switzerland
Epidemiology, Biostatistics and Prevention Institute University of Zurich
RECRUITING
Zurich
Epidemiology, Biostatistics and Prevention Institute University of Zurich
RECRUITING
Zurich
Contact Information
Primary
Phung Lang, Ph.D.
phung.lang@uzh.ch
+41 44 634 46 72
Backup
Kyra Zens, Ph.D.
zens@immunology.uzh.ch
+41 44 634 46 72
Time Frame
Start Date:2023-12-01
Estimated Completion Date:2025-09-01
Participants
Target number of participants:200
Treatments
Experimental: MMR Booster Vaccination Arm
Participants (adults 18+ having previously received 2 lifetime doses of MMR-containing vaccine) will receive a single MMR booster vaccination (3rd lifetime dose) as M-M-R-VaxPro.
No_intervention: Observational Arm
Participants (adults 18+ having previously received 2 lifetime doses of MMR-containing vaccine) will be assessed at study enrollment and at a 1 year follow-up visit