The Characteristics of Gut Microbiota in Patients With Sarcopenia and the Development of Probiotics
The primary aim of this study is to identify the composition and characteristics of the gut microbiota in patients with sarcopenia in older adults, and compare these with the gut microbiota characteristics of older adults and young control groups to determine differences. Secondary purpose of this study is to provide data on the characteristics of gut microbiota for the development of probiotics effective in treating sarcopenia in older adults.
• Sarcopenia patient group
‣ Individuals aged 65 to 90 years
⁃ Meet the diagnostic criteria for sarcopenia based on the 2019 Asian Working Group for Sarcopenia (AWGS) guidelines:
⁃ Low appendicular skeletal muscle mass
• DEXA: \<7.0 kg/m² (men), \<5.4 kg/m² (women)
∙ BIA: \<7.0 kg/m² (men), \<5.7 kg/m² (women)
⁃ Low muscle strength
• Handgrip strength: \<28 kg (men), \<18 kg (women) or
⁃ Low physical performance
• 6-meter walk speed \<1.0 m/s
∙ 5-chair stand test ≥12 seconds
∙ Short Physical Performance Battery (SPPB) score ≤9
⁃ Voluntarily agree to participate in the clinical study and sign the informed consent form
• Older adult control group
‣ Individuals aged 65 to 90 years
⁃ Voluntarily agree to participate in the clinical study and sign the informed consent form
• Young adult control group
‣ Individuals aged 20 to 50 years
⁃ Voluntarily agree to participate in the clinical study and sign the informed consent form