Clinical Transformation of Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Avascular Necrosis of Femur Head
The commercial decalcified bone scaffold combined with the patient's autologous bone marrow mesenchymal stem cells was used for in vitro culture to form tissue-engineered bone, and the effect of this tissue-engineered bone in early non-traumatic femoral head necrosis was explored.
• Capable of understanding and voluntarily signing the informed consent form before the study;
• Meets the diagnostic criteria in the Clinical Diagnosis and Treatment Guidelines for Adult Femoral Head Necrosis in China (2020);
• Age range: 20 - 65 years old (inclusive of boundary values), gender not restricted;
• Staged as ARCO II stage;
• Non-traumatic femoral head necrosis;
• Has received conservative treatment (such as physical therapy, blood-activating, analgesic drugs, etc.) for more than 2 weeks, and the target hip joint still shows persistent pain symptoms;
• The subjects are usually able to move, not bedridden or in a wheelchair for a long time, and can walk more than 50 meters without the help of crutches or walking sticks;
• During the trial period and within 90 days after the surgery, the subjects have no pregnancy plans and voluntarily take effective contraceptive measures.