What is the definition of Nephrosclerosis?

Nephrosclerosis is a progressive condition in which a hardening of the kidney and damage to the renal arteries, veins, arterioles, glomeruli, renal tubules, and interstitial tissues occurs due to fibrous connective tissue (fibrosis) caused by kidney and vascular diseases or chronic high blood pressure (hypertension). Nephrosclerosis leads to the development of chronic kidney disease, eventually progressing to end-stage renal disease in some patients. Nephrosclerosis occurs more often in black individuals of African descent.

What are the symptoms for Nephrosclerosis?

Symptoms of nephrosclerosis may include loss of appetite; nausea; vomiting; itching; confusion; excessive sleepiness; unexplained weight loss; and damage to the blood vessels of the eyes, skin, central nervous system (CNS), and peripheral nerves.

What are the current treatments for Nephrosclerosis?

Treatment for nephrosclerosis is focused on strict blood pressure control and support of kidney function and may include medications such as diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, renin inhibitors, calcium channel blockers, beta-adrenergic blocking agents, direct-acting vasodilators, and alpha 2-adrenergic agonists, among others.