Nonalcoholic Steatohepatitis in Chinese Children: a Long Term Follow-up

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality. A growing body of evidence suggests that children with NASH frequently show histopathological features that differ from those of adults. The prevalence of this pattern in a wide range of paediatric cases as well as other histopathological lesions and their relevance and prognostic significance in children with NAFLD remains to be determined. Thus the investigators would like to conduct a study of biopsies and clinical information to document the histological features of paediatric NAFLD, to explore the natural history of paediatric NAFLD, and to determine the frequency and prognostic value of these features.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 18
View:

• age 1-18 with biopsy-proven NAFLD

• Alcohol consumption less than 20g/day and 10g/day for boys and girls respectively

Locations
Other Locations
China
Children's Liver Disease Center, 302 Hospital
RECRUITING
Beijing
Contact Information
Primary
George Lau, MD, PhD
gkklau@hnhmgl.com
852-28613777
Backup
Yudong Wang, MD, PhD
danny.wang@hnhmgl.com
852-28184300
Time Frame
Start Date: 2017-05-01
Estimated Completion Date: 2028-05-31
Participants
Target number of participants: 400
Sponsors
Collaborators: Beijing 302 Hospital
Leads: Humanity and Health Research Centre

This content was sourced from clinicaltrials.gov