Time-restricted Feeding to Mitigate Metabolic Impairments During Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.
• 18-35 old; men and women; equal numbers of women and men will be included.
• Body Mass Index (BMI) between 20.0 and 24.9 (normal weight).
• Physical activity history: inactive to habitual moderate physical activity level
• Sleep/wake history: habitual sleep duration between 7-9.25 hours.
• Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.