Impact of Circadian Misalignment on Energy Balance Regulation

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and interoception; supporting a role of sleep and meal misalignment, on energy balance regulation. No study has been done to disentangle the effects of sleep and meal timing on body weight regulation, independent of sleep duration. This study will provide information to guide messaging related to timing of meals and sleep that can be translated to individuals whose sleep follows unconventional times, such as shift workers and those with jetlag and social jetlag.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 49
Healthy Volunteers: t
View:

• All racial and ethnic groups

• Body mass index 20-34.9 kg/m2

• Average sleep duration ≥7 hour/night, assessed during 2-week screening period

• Eat within 1 hour of awakening at least 5 days/week

• Midpoint of sleep at 4 AM or earlier

Locations
United States
New York
Columbia University Irving Medical Center
RECRUITING
New York
Contact Information
Primary
Diane Hawkins
dh3078@cumc.columbia.edu
212 305 9379
Time Frame
Start Date: 2019-01-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 42
Treatments
Experimental: Circadian misalignment
Meals in this condition will be delayed by 4 hours relative to the circadian alignment condition. Food intake during this period will be from 1 PM to 11 PM.
Active_comparator: Circadian alignment
Meals in this condition will be aligned to the sleep episode. Food intake during this period will be from 9 AM to 7 PM.
Related Therapeutic Areas
Sponsors
Collaborators: NYU Langone Health
Leads: Columbia University

This content was sourced from clinicaltrials.gov