Assessment of Pancreatic Beta Cell Mass and Function with the Aid of Positron Emission Tomography Imaging in Human Diabetes Mellitus
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goals of this project are to build an experimental tool to dissect out in vivo pancreatic beta cell mass (BCM) and beta cell function (BCF) and to assess for the first time these two determinants of beta cell functional mass (BCFxM) in obesity and in various stages of type 1 and type 2 diabetes mellitus.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age ≥18 years; ≤ 75 years
• Both sexes
• Good health
• Absence of exclusion criteria
• Able to understand methods, goals, and implications of the research and of delivering a free, written informed consent
Locations
Other Locations
Italy
Azienda Ospedaliero Universitaria di Parma
RECRUITING
Parma
Contact Information
Primary
Riccardo Bonadonna, MD
riccardo.bonadonna@unipr.it
+390521033307
Time Frame
Start Date: 2022-03-15
Estimated Completion Date: 2025-12
Participants
Target number of participants: 70
Treatments
Other: long standing type 1 diabetes (> 20 yrs)
68Ga-exendin4 PET-CT scan +mixed meal test
Other: newly diagnosed type 1 diabetes (< 5yrs)
68Ga-exendin4 PET-CT scan +mixed meal test
Other: long standing type 2 diabetes (> 20 yrs)
68Ga-exendin4 PET-CT scan +mixed meal test
Other: newly diagnosed type 2 diabetes (<6 months)
68Ga-exendin4 PET-CT scan +mixed meal test
Other: pre-diabetes
68Ga-exendin4 PET-CT scan +mixed meal test
Other: hyperinsulinemic
68Ga-exendin4 PET-CT scan +mixed meal test
Other: control
68Ga-exendin4 PET-CT scan +mixed meal test
Related Therapeutic Areas
Sponsors
Leads: Azienda Ospedaliero-Universitaria di Parma
Collaborators: University of Parma