Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function: From Mice to Children
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Maximum Age: 16
Healthy Volunteers: f
View:
• Children aged 12 to 16 years
• Obesity. Defined as a body-mass index above the 97th percentile.
• Ability to give informed consent as documented by signature
Locations
Other Locations
Switzerland
University Hospital of Geneva
RECRUITING
Geneva
Contact Information
Primary
Philippe Klee
philippe.klee@unige.ch
+41 79 55 33 476
Backup
Pierre Maechler
pierre.maechler@unige.ch
Time Frame
Start Date: 2024-11-22
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 50
Treatments
Children with obesity
Children with obesity followed within the pediatric endocrine and diabetes unit of the University Hospitals of Geneva, Switzerland. The investigators will do prospective measures in 50 children aged 12 to 15 years, at the time of a planned oral glucose tolerance test and again, 2 years later.
Related Therapeutic Areas
Sponsors
Collaborators: University of Geneva, Switzerland
Leads: Philippe Klee, MD-PhD