The Effects of a 12-week Combined Exercise Intervention on the Gut Microbiome of Older Adults

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

There are trillions of microorganisms living alongside us in our guts. Recent research has shown that this community, known as the gut microbiome, has a big influence on our health and wellbeing. Imbalances in the composition of the gut microbial community has been linked to several diseases including COVID, mental ill health, and diabetes. When the composition of the gut microbiome changes towards a less healthy one (called dysbiosis) this will, in turn, affect our health in a negative way. The composition of our gut microbiome remains fairly stable during adulthood, however, as we move into older age, there is a shift and its composition will change to a less healthy one; this is one of the reasons why older people can be more susceptible to diseases. Fortunately, there are several tools that we can use to improve our gut microbiome and one of them is exercise. Besides its well-known effects on our health, exercise has been shown to be able to improve the gut microbiome composition of younger people and those with certain metabolic diseases such as obesity. However, less is known about the effects of exercise on the gut microbiome of older adults. The aim of this study, therefore, is to assess the effects of a 12-week exercise intervention on the gut microbiome of physically inactive older adults. Hopefully, after this study, the investigators will have more information on whether exercise can be used as a tool to improve the gut microbiome of older adults therefore improving their overall health and quality of life.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 85
Healthy Volunteers: t
View:

• Aged between 65-85 years old

• Healthy, free-living individuals

• Vaccinated against COVID-19

• Physically inactive (\<150 mins/week of PA)

• No participation in any exercise intervention studies in the last 3 months

• BMI Between 20-35 kg/m2

Locations
Other Locations
United Kingdom
Nottingham Trent University - Clifton campus
RECRUITING
Nottingham
Contact Information
Primary
Kirsty Hunter
kirsty.hunter@ntu.ac.uk
+44 (0)115 848 3069
Time Frame
Start Date: 2023-12
Estimated Completion Date: 2024-06
Participants
Target number of participants: 80
Treatments
Active_comparator: Exercise group
Placebo_comparator: Control group
Related Therapeutic Areas
Sponsors
Leads: Nottingham Trent University
Collaborators: University of Reading

This content was sourced from clinicaltrials.gov