Longitudinal Monitoring During Different Intermittent Fasting Protocols in Obese Adults - a Randomized Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

LIMITFOOD2 is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of obese adults. A total of 90 participants will be randomized into three equally sized groups: a modified alternate day fasting, a time-restricted eating and a control group, receiving general weight-loss counseling.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
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• Age between 18-50 years, both inclusive

• Obese, BMI between 30 and 40 kg/m\^2 (obesity grade I or II), both inclusive

• Non-smoker

• Good knowledge of German or English language

• Stable weight change (change \< +/- 3% current bodyweight) for 3 months prior to the study

• HbA1c \< 6.5% without glucose lowering medication

• LDL-cholesterol \< 4.6mmol/l without lipid lowering medication

Locations
Other Locations
Switzerland
Department of Endocrinology, Diabetology and Clinical Nutrition
RECRUITING
Zurich
Contact Information
Primary
Leonie Mönch, MSc
leonie.moench@usz.ch
+41 44 255 31 64
Time Frame
Start Date: 2024-09-23
Estimated Completion Date: 2027-01
Participants
Target number of participants: 90
Treatments
Active_comparator: Modified Alternate Day Fasting (mADF)
Participants in the mADF group will be instructed to eat every second-day ad libitum (feast days), and to consume a very low carbohydrate snack, restricted to the evening, provided by the study team and to otherwise abstain from calorie intake on the rest of the fast day.
Active_comparator: Time-Restricted Eating (TRE)
TRE participants are instructed to eat two main meals and limit snacking from 12:00 to 20:00 daily, and to fast from 20:00 until 12:00 daily
Other: Control group
The control group will receive guidance on a quantitative reduction in total caloric intake by following a balanced diet, but no timing window for food intake will be prescribed to the participants in the control group.
Related Therapeutic Areas
Obesity
Sponsors
Leads: University of Zurich

This content was sourced from clinicaltrials.gov

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