Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort (Pro-Metage)
The goal of this prospective observational study is to identify and validate blood based aging biomarkers in relation to cardiometabolic phenotypes of young and old, female and male subjects with or without obesity. The main question is to gain insights into the interaction of obesity related metabolic alteration and aging, and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies.
⁃ Group 1 - Lean, young adults (n = 150)
• Age 18 - 35 years
• Body mass index (BMI) ≥ 18.5 and ≤ 24.9 kg/m2 (≥ 12 months)
⁃ Group 2 - Overweight, young adults (n = 150)
• Age 18 - 35 years
• BMI ≥ 28kg/m2 (≥ 12 months)
⁃ Group 3 - Lean, older adults (n = 150)
• Age ≥ 60 years
• BMI ≥ 18.5 and ≤ 24.9 kg/m2 (≥ 3 years)
⁃ Group 4 - Overweight, older adults (n = 150)
• Age ≥ 60 years
• BMI ≥ 28 kg/m2 (≥ 3 years)
• Subgroup A (n=75): with pre-existent cardiovascular disease defined as: history of myocardial infarction or evidence of coronary artery disease irrespective of revascularization status or history of ischemic or hemorrhagic stroke or presence of peripheral artery disease or heart failure with preserved ejection fraction (NYHA Class I-II).
• Subgroup B (n=75): without pre-existent cardiovascular disease
⁃ Group 5 - Nonagenerians Age ≥ 90 (n = 50)
• Age ≥ 90 years
• BMI ≥ 18.5 kg/m2 (≥ 3 years)