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Direct Measurement of Ingestive Behaviour in Relation to Sex Differences and Gastrointestinal Hormone Levels in Patients After Metabolic and Bariatric Surgery

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Bariatric surgery (BS), especially procedures like Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), is the most effective treatment for obesity. Yet, the exact mechanisms governing its effect are somewhat elusive, with current research mainly focusing on post-operative food intake outcomes based on self-reported data, which might not fully capture the nuanced changes in eating behaviours. To address these gaps, our study plans to employ the newly developed drinkometer, a device capable of analysing the intricate changes in drinking behaviour following BS. This tool promises to bring a more detailed perspective to the changes in ingestive behaviours, bypassing the inaccuracies of self-reporting methods. By expanding our research to encompass diverse patient demographics and examining potential links to physiological shifts like gut hormone level alterations, the study aims to provide a more rounded understanding of the long-term impacts of BS on eating behaviours.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Age ≥ 18 year

• BMI ≥ 35 kg/m2 for patients with planned RYGB or SG operation

• BMI ≥ 30 kg/m2 for external controls affected by obesity but no planned RYGB or SG within the next 12 months, and

• BMI ≥ 18.5 kg/m2 and ≤ 24.9 kg/m2 for controls without obesity.

Locations
Other Locations
Switzerland
Hospital Männedorf
RECRUITING
Männedorf
University Hospital Zurich, Department of Surgery and Transplantation
RECRUITING
Zurich
Contact Information
Primary
Marco Bueter, MD, DPhil
m.bueter@spitalmaennedorf.ch
+41442558895
Backup
Michele Serra, PhD
michele.serra@uzh.ch
+41762226763
Time Frame
Start Date: 2024-02-13
Estimated Completion Date: 2027-08-31
Participants
Target number of participants: 420
Treatments
Adult Females planned for RYGB surgery
Adult females leaving with obesity with BMI between 35 and 50 kg/m2 and scheduled for Roux-en-Y Gastric Bypass Surgery
Adult Females planned for SG surgery
Adult females leaving with obesity with BMI between 35 and 50 kg/m2 and scheduled for Sleeve Gastrectomy Surgery
Adult Females with Obesity
Adult females leaving with obesity with BMI between 30 and 50 kg/m2 but not scheduled for any procedures of bariatric surgery
Adult Females with Normal-Weight
Adult females with normal weight with BMI between 18.5 and 24.9 kg/m2
Adult Males planned for RYGB surgery
Adult males leaving with obesity with BMI between 35 and 50 kg/m2 and scheduled for Roux-en-Y Gastric Bypass Surgery
Adult Males with Obesity
Adult males leaving with obesity with BMI between 30 and 50 kg/m2 but not scheduled for any procedures of bariatric surgery
Adult Males with Normal-Weight
Adult males with normal weight with BMI between 18.5 and 24.9 kg/m2
Adult Females and Males 5 years after RYGB surgery
Adult Females and Males who underwent RYGB surgery 5 years before study recruitment and study measurements
Related Therapeutic Areas
Sponsors
Collaborators: Florida State University, University College Dublin
Leads: University of Zurich

This content was sourced from clinicaltrials.gov