Total-body Glucose Utilization in Obesity
Status: Recruiting
Location: See location...
Intervention Type: Radiation, Behavioral, Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
There are three goals for this study. One is to investigate how different emotions and exposure to cold affect blood flow in the body. The second aim is to study how insulin affects blood flow and tissue glucose uptake, and to study whether this effect is altered in obesity. Last, the study focuses on establishing the lowest dose of a PET radiotracer, oxygen-15 labelled water, that can be used in clinical studies with a new whole-body PET scanner.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 60
Healthy Volunteers: t
View:
• Age 20-60 years
• BMI either 18.5-25 kg/m2 or above 30 kg/m2
• Use of hormonal contraception for women in child bearing age
Locations
Other Locations
Finland
Turku PET Centre
RECRUITING
Turku
Contact Information
Primary
Aino Latva-Rasku, MD, PhD
aehyyp@utu.fi
358+23139857
Backup
Sanna Himanen, RN
sanna.himanen@varha.fi
358+469200200
Time Frame
Start Date: 2023-01-25
Estimated Completion Date: 2024-12
Participants
Target number of participants: 60
Treatments
Experimental: TOTAL dose test
The aim of the studies performed in this arm (8 subjects) is to test the lowest dose of H2\[15O\]O (radiowater) for the Siemens Quadra PET/CT scanner. Each participant will be studied once with the scanner with 4 different doses (25-700 MBq) of H2\[15O\]O, each repeated 2 times
Experimental: TOTAL
The participants in this arm will undergo two PET visits. On one visit the effects of visual stimuli or cold on whole body perfusion will be studied with H2\[15O\]O PET/CT. On the second visit whole-body insulin sensitivity is studied with \[18F\]fluorodeoxyglucose PET/CT, and the acute and delayed effects of intravenous insulin on blood flow will be studied with H2\[15O\]O PET/CT.
Related Therapeutic Areas
Sponsors
Leads: Turku University Hospital