Effect of Ketone Esters on Liver Fat and Metabolic Function in Adolescents With Obesity and MASLD
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control. Ketones are a type of energy source made by the body during times of weight loss, low carbohydrate intake and starvation. People enrolled in this study will be randomly assigned (by chance, like the flip of a coin) to one of two groups: Group 1: Ketone ester drink consumed daily for 6 weeks. Group 2: Placebo drink consumed daily for 6 weeks.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 25
Healthy Volunteers: t
View:
• Age: ≥18 and ≤25 years;
• BMI 25.0 - 44.9 kg/m2;
• Intrahepatic triglyceride content \>5% assessed by using magnetic resonance imaging-proton density fat fraction (MRI-PDFF).
Locations
United States
Missouri
Washington University School of Medicine
RECRUITING
St Louis
Contact Information
Primary
Nikki Plassmeyer, RDN, LD
nikkip@wustl.edu
314-362-0590
Backup
Central contact information
nutritionresearch@wustl.edu
314-273-1879
Time Frame
Start Date: 2025-09-26
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 40
Treatments
Placebo_comparator: Placebo
25 g Placebo per day for approximately 6-weeks
Experimental: C8 ketone di-ester
25 g C8 ketone di-ester per day for approximately 6-weeks
Related Therapeutic Areas
Sponsors
Leads: Washington University School of Medicine
Collaborators: Children's Discovery Institute