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Effect of Once-weekly Subcutaneous Administration of NNC0487-0111 on Energy Intake, Appetite and Postprandial Metabolism in Participants With Obesity - a Randomised, Placebo-controlled, Double Blinded Study

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The purpose of this clinical study is to look at if/how much NNC0487-0111 affects food intake, appetite and metabolism in participants with obesity when compared to placebo. There are 2 study treatments in this study. Participants will inject the study treatment under the skin of your stomach once a week. Participants will get either NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants will get is decided by chance.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 64
Healthy Volunteers: f
View:

• Male or female (sex at birth).

• Age 18-64 years (both inclusive) at the time of signing the informed consent.

• Considered eligible based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator.

• Overweight should be due to excess adipose tissue, as judged by the investigator.

Locations
Other Locations
Germany
Parexel International GmbH
RECRUITING
Berlin
Contact Information
Primary
Novo Nordisk
clinicaltrials@novonordisk.com
(+1) 866-867-7178
Time Frame
Start Date: 2026-03-30
Estimated Completion Date: 2028-01-22
Participants
Target number of participants: 120
Treatments
Experimental: NNC0487-0111
Participants will be randomized to receive 1 of the different dose levels of NNC0487-0111 subcutaneously once weekly.
Placebo_comparator: Placebo
Participants will receive placebo matched to NNC0487-0111 subcutaneously once weekly.
Related Therapeutic Areas
Sponsors
Leads: Novo Nordisk A/S

This content was sourced from clinicaltrials.gov