A PHASE 1, OPEN-LABEL, MULTIPLE DOSE STUDY TO INVESTIGATE THE IMPACT OF PF 08653944 ON GASTRIC EMPTYING IN ADULT PARTICIPANTS WITH OVERWEIGHT OR OBESITY
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
This study looks at how a study medicine called PF-08653944 affects how quickly the stomach empties food after eating. It is being done in adults who are overweight or have obesity. Participants will receive the study medicine for a short period, and doctors will measure how the medicine moves through the stomach and monitor safety. The goal is to better understand how this medicine works in the body and to check for any side effects. The information from this study may help researchers plan future studies of this medicine.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: t
View:
• Adults ≥18 years at screening, male or female, generally healthy as determined by medical history, physical examination, laboratory tests, and ECG.
• Body mass index (BMI) 27-45 kg/m² and body weight \>50 kg (110 lb).
• Participants with overweight or obesity
Locations
United States
Connecticut
Pfizer Clinical Research Unit - New Haven
RECRUITING
New Haven
Contact Information
Primary
Pfizer CT.gov Call Center
ClinicalTrials.gov_Inquiries@pfizer.com
1-800-718-1021
Time Frame
Start Date:2026-03-31
Estimated Completion Date:2027-01-27
Participants
Target number of participants:20
Treatments
Experimental: Period 1
Participants will receive a single oral dose of acetaminophen.
Experimental: Period 2
Participants will receive SC dose of PF-08653944 and single oral dose of acetaminophen.
Experimental: Period 3
Participants will receive SC dose of PF-0865394.
Experimental: Period 4
Participants will receive SC dose of PF-0865394.
Experimental: Period 5
Participants will receive SC dose of PF-08653944 and single oral dose of acetaminophen.
Experimental: Period 6
Participants will receive single SC dose of PF-08653944 and single oral dose of acetaminophen.