Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• BMI ≥ 25-30 kg/m2
• BMI ≥ 30 kg/m2 with Metabolic syndrome
• BMI ≥ 35 kg/m2 for morbid obesity
Locations
Other Locations
Hong Kong Special Administrative Region
The Chinese University of Hong Kong, Prince of Wale Hospital
RECRUITING
Hong Kong
Contact Information
Primary
Winnie C Chu, MD
winniechu@cuhk.edu.hk
(852) 3505 2299
Time Frame
Start Date: 2019-04-01
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 80
Treatments
Experimental: Morbid obesity- Bariatric surgery group
Morbid obese subjects who will consent to bariatric surgery
Experimental: Morbid obesity-Dietitian led life style intervention group
Morbid obese subjects who will not consent to bariatric surgery but instead opt for dietitian led life style intervention
Experimental: Mild obesity-Dietitian led life style intervention group
Mild- Moderate subjects assigned through a randomized controlled trial to the dietitian led life style intervention
Experimental: Mild obesity-Conventional care group (control)
Mild- Moderate subjects assigned through a randomized controlled trial to conventional care
Related Therapeutic Areas
Sponsors
Leads: Chinese University of Hong Kong