Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCD

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD). Researchers will compare three groups: ERP with one of two different active (real) forms of TMS vs. ERP with sham (fake) TMS. The main questions this study aims to answer are: 1) whether TMS normalizes functioning in brain circuits that contribute to compulsive behavior, and 2) whether TMS reduces compulsions during ERP. Participants will: * Complete clinical interviews, questionnaires, and computerized tasks * Complete two MRIs (brain scans) * Receive daily TMS followed by ERP for two weeks (10 sessions)

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Maximum Age: 21
Healthy Volunteers: f
View:

• Between the ages of 12 and 21 years.

• Presence of OCD, as indicated by a score of \> 16 on the Children's Yale-Brown Obsessive Compulsive Scale, indicating moderate or greater OCD symptoms.

• Presence of motor compulsions on CY-BOCS compulsion checklist

• English fluency to ensure comprehension of informed consent and study measures and instructions.

Locations
United States
Minnesota
University of Minnesota
RECRUITING
Minneapolis
Rhode Island
Emma Pendleton Bradley Hospital
RECRUITING
Riverside
Contact Information
Primary
Kristen Benito, PhD
kbenito@lifespan.org
410-432-1054
Backup
Christine Conelea, PhD
cconelea@umn.edu
Time Frame
Start Date: 2024-03-20
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 60
Treatments
Experimental: ERP+iTBS
Participants will receive two weeks (10 sessions) of intermittent theta burst stimulation (iTBS; a form of TMS) targeting the dorsolateral prefrontal cortex (dlPFC), followed immediately by Exposure Plus Response Prevention (ERP).
Experimental: ERP+cTBS
Participants will receive two weeks (10 sessions) of continuous theta burst stimulation (cTBS; a form of TMS) targeting the presupplementary motor area (pSMA), followed immediately by Exposure Plus Response Prevention (ERP).
Active_comparator: ERP+Sham
Participants will receive two weeks (10 sessions) of sham (fake) TMS, followed immediately by Exposure Plus Response Prevention (ERP).
Related Therapeutic Areas
Sponsors
Collaborators: Butler Hospital, University of Minnesota
Leads: Bradley Hospital

This content was sourced from clinicaltrials.gov