Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents. The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD. Participants will: * visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments * have a brain MRI scan before TMS treatments begins and after finishing all TMS * complete questionnaires and report changes in behavior and physical symptoms

Eligibility
Participation Requirements
Sex: All
Minimum Age: 13
Maximum Age: 17
Healthy Volunteers: f
View:

• outpatients

• ages 13 - 17 years

• meets current DSM-5 criteria for Obsessive Compulsive Disorder with screening CY-BOCS II score \> 16 (moderate to severe).

• stable on chronic psychotropic medications and/or therapy for 8 weeks prior to the study and agreeable to continue throughout the study without changes.

• participants may continue to take medications and record daily usage throughout the study.

• capacity to provide informed assent and parent or legal guardian able to provide consent.

• ability to tolerate clinical study procedures.

• successfully complete the screening forms without any contraindications.

Locations
United States
California
University of California, San Francisco
RECRUITING
San Francisco
Contact Information
Primary
Starlette Khim, BA
ocdteenTMS@ucsf.edu
415-514-5743
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2027-07-01
Participants
Target number of participants: 30
Treatments
Experimental: Right Orbitofrontal TBS
continuous theta burst stimulation
Active_comparator: TBS of dorsal, medial prefrontal cortex
intermittent theta burst stimulation (iTBS) will be delivered to the dmPFC
Related Therapeutic Areas
Sponsors
Collaborators: Hearst Foundations
Leads: University of California, San Francisco

This content was sourced from clinicaltrials.gov