A Prospective Study of Low Dose Radiotherapy for Osteoarthritis
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• 18 years or older
• Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows.
• Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
• Provision of signed and dated informed consent.
Locations
United States
Pennsylvania
Penn Presbyterian Medical Center
RECRUITING
Philadelphia
Perelman Center for Advanced Medicine
RECRUITING
Philadelphia
Contact Information
Primary
Marlowe Estioko, BS, MS
Marlowe.Estioko@Pennmedicine.upenn.edu
267-343-6483
Backup
Sonya George, BS
Sonya.George@PennMedicine.upenn.edu
267-760-7636
Time Frame
Start Date: 2026-06-24
Estimated Completion Date: 2029-06
Participants
Target number of participants: 113
Treatments
Other: Single
Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.
Related Therapeutic Areas
Sponsors
Leads: Abramson Cancer Center at Penn Medicine