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Outcome of Bone Marrow Injection at Fracture Site in Intracapsular Fracture of Femoral Neck Treated by Head Preserving Surgery

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Objectives: * Primary objective : * To investigate the predisposing factors for femoral neck fractures, including age, sex, and associated comorbidities. * To investigate the complications associated with intracapsular femoral neck fractures, particularly in young patients. * To evaluate the effectiveness of autologous bone marrow injection at the femoral neck fracture site and its effect on: * Achieving complete fracture union. * Reducing the time required for fracture healing. * Reducing the incidence of avascular necrosis of the femoral head. * Secondary objective: The study addresses the challenge of performing total hip arthroplasty in young patients. Complications following intracapsular femoral neck fractures, particularly avascular necrosis and nonunion, may ultimately necessitate this treatment option. However, total hip arthroplasty is generally less desirable in young patients because of: * Early prosthetic loosening. * The potential need for revision arthroplasty later in life due to wear and deterioration of prosthetic components over time. * Higher complication rates and lower long-term success rates. In this study, we will focus on the use of fully threaded cannulated screws combined with bone marrow injection into the fracture site, and evaluate their effect on the healing and union of intracapsular femoral neck fractures.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: f
View:

• Age between 18 and 55 years.

• Intracapsular femoral neck fracture classified as Garden type III or IV.

• The time elapsed since the fracture occurred must not exceed 24 hours

Locations
Other Locations
Syrian Arab Republic
Idlib university Faculty of medicine
RECRUITING
Idlib
Contact Information
Primary
Mohamad M ISSA, MD
mohamadalessa888@gmail.com
0954233150
Time Frame
Start Date: 2025-05-12
Estimated Completion Date: 2027-08-01
Participants
Target number of participants: 32
Treatments
Active_comparator: Group A:fixation using three fully threaded cancellous
Patients will undergo surgical intervention on the fractured hip under appropriate anesthesia. Anatomical reduction of the fracture will be achieved under fluoroscopic guidance, followed by fixation through a lateral surgical approach to the hip using three fully threaded cancellous screws.
Experimental: Group B: Fixation using three fully cancellous screws with injection of autologous bone marrow
Patients will undergo the same surgical procedure under appropriate anesthesia, with anatomical reduction of the fracture achieved under fluoroscopic guidance. The fracture will then be fixed through a lateral surgical approach using three fully threaded cancellous screws, in addition to the following procedure After drilling through the lateral femoral cortex toward the fracture line and advancing to the femoral head up to the subchondral bone, approximately 1-1.5 cm below the articular surface of the femoral head, 15 mL of autologous bone marrow will be aspirated from the iliac crest, approximately 1 cm posterior to the anterior superior iliac spine (ASIS), after ensuring that the site is included within the surgical field. The aspirate will be distributed into three heparin-prepared tubes.~The harvested autologous bone marrow will then be injected through the prepared screw channels to ensure delivery of the graft to the fracture site.~The screws will subsequently be inserted.
Related Therapeutic Areas
Sponsors
Leads: Yaser Alkanash

This content was sourced from clinicaltrials.gov