GLP-1R Actions on Muscle and the Skeleton
The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.
• Subjects will have a BMI between 30kg/m2
⁃ 40kg/m2 (inclusive)
• Be between 18 and 50 years of age (inclusive).
• Non-Hispanic Black males and females will be enrolled at PBRC.
• Rural males and females will be enrolled at MaineHealth.
• Female subjects will be premenopausal.
• Females have had their last menstrual period less than 60 days before screening.
• Females have the absence of menopausal-associated vasomotor symptoms.
• All subjects must be able to use Lifestyle Toolkit as prescribed for intervention arm.