⁃ Cohort 1: Advanced Pancreatic Cancer Cohort Inclusion Criteria

• Radiological, histological or cytological confirmed diagnosis of locally advanced or metastatic pancreatic adenocarcinoma by the enrolling institution

• Patient planning to receive systemic treatment

• Hemoglobin \> 8

• ECOG performance status 0-2

• A minimum age of 18 years old

• Willing to undergo a tumor biopsy

• Willing to provide permission to obtain banked tumor tissue for analysis (previous biopsies or surgical material).

⁃ Cohort 2: Operable Pancreatic Cancer Cohort Inclusion Criteria

• Radiological, histological or cytological confirmed diagnosis of pancreatic adenocarcinoma by the enrolling institution

• Patient planned to undergo upfront resection

• No pre-operative systemic therapy nor chemoradiation therapy planned

• Hemoglobin \> 8

• ECOG performance status 0-2

• A minimum age of 18 years old

• Willing to undergo a tumor biopsy

• Willing to provide permission to obtain banked tumor tissue for analysis (previous biopsies or surgical material).

⁃ Cohort 3: Acute Benign Pancreatic Pathology Control Inclusion Criteria

• Confirmed diagnosis of acute pancreatitis or other acute pancreatic pathology by the enrolling institution

• Hemoglobin \> 8

• ECOG performance status 0-2

• A minimum age of 18 years old

⁃ Cohort 4: Chronic Benign Pancreatic Pathology Control Inclusion Criteria

• Confirmed diagnosis of chronic pancreatitis or other non-cystic chronic pancreatic pathology by the enrolling institution

• Hemoglobin \> 8

• ECOG performance status 0-2

• A minimum age of 18 years old

⁃ Cohort 5: IPMN Control Inclusion Criteria

• Confirmed diagnosis of IPMN without high risk features by the enrolling institution

• A minimum age of 18 years old

⁃ Cohort 6: Pancreatic Cyst Control Inclusion Criteria

• Confirmed diagnosis of benign pancreatic cyst by the enrolling institution

• A minimum age of 18 years old

⁃ Cohort 7: Healthy Control Inclusion Criteria

• A minimum age of 18 years old