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Latest Advances in
Paroxysmal Nocturnal Hemoglobinuria
Overview
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Clinical Trials
Latest Advances
Condition:
Non-Severe Aplastic Anemia
Journal:
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Treatment Used:
Cyclosporin A (CsA) with Recombined Human Thrombopoietin (rhTPO)
Number of Patients:
83
Published —
September 18, 2020
This study tested the safety and efficacy of using CsA combined with rhTPO to treat patients with non-severe aplastic anemia.
Condition:
Paroxysmal Nocturnal Hemoglobinuria (PNH) Complicated with Iron Deficiency Anemia
Journal:
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Treatment Used:
Iron Therapy
Number of Patients:
48
Published —
September 18, 2020
This study evaluated the effectiveness and safety of iron supplementation in patients with paroxysmal nocturnal hemoglobinuria (an acquired disorder that leads to the premature death and impaired production of blood cells; PNH) with iron deficiency.
Condition:
Paroxysmal Nocturnal Hemoglobinuria
Journal:
PloS one
Treatment Used:
Ravulizumab or Eculizumab
Number of Patients:
98
Published —
September 04, 2020
This study compared the clinical outcome of using ravulizumab or eculizumab to treat patients with paroxysmal nocturnal hemoglobinuria.
Condition:
Paroxysmal Nocturnal Hemoglobinuria
Journal:
[Rinsho ketsueki] The Japanese journal of clinical hematology
Treatment Used:
Eculizumab
Number of Patients:
8
Published —
July 07, 2020
This study tested the safety and efficacy of using eculizumab to treat patients with paroxysmal nocturnal hemoglobinuria.
Condition:
Paroxysmal Nocturnal Hemoglobinuria
Journal:
Annals of hematology
Treatment Used:
Eculizumab
Number of Patients:
0
Published —
June 17, 2020
In this study, researchers evaluated the outcomes of eculizumab therapy for the treatment of paroxysmal nocturnal hemoglobinuria.
Condition:
Children With Severe Aplastic Anemia
Journal:
Zhongguo shi yan xue ye xue za zhi
Treatment Used:
reduced dose of cyclophosphamide combined cyclosporine A
Number of Patients:
10
Published —
February 07, 2020
The purpose of the study was to analyze the clinical efficacy and side effects of reduced-dose of cyclophosphamide combined with cyclosporine A for severe aplastic anemia children.
Condition:
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Journal:
Blood
Treatment Used:
Crovalimab
Number of Patients:
29
Published —
January 25, 2020
This study assessed the safety, effectiveness, pharmacokinetics, and pharmacodynamics of C5 inhibitor, crovalimab, in patient with paroxysmal nocturnal hemoglobinuria (rare blood disorder).
Condition:
Pediatric Hepatic Venous Outflow Tract Obstruction
Journal:
Indian pediatrics
Treatment Used:
Angioplasty or Liver Transplantation
Number of Patients:
11
Published —
November 16, 2019
This study reviewed case records of children diagnosed with hepatic venous outflow tract obstruction.
Condition:
Severe Aplastic Anemia
Journal:
Haematologica
Treatment Used:
Antithymocyte Globulin and Cyclosporine with or without Granulocyte Colony-stimulating Factor (G-CSF)
Number of Patients:
192
Published —
October 05, 2019
In this study, researchers evaluated the outcomes of treating severe aplastic anemia with antithymocyte globulin and cyclosporine, with or without granulocyte colony-stimulating factor (G-CSF).
Condition:
Relapsed and Refractory Aplastic Anemia-Paroxysmal Nocturnal Hemoglobinuria Syndrome (AA-PNH)
Journal:
Zhongguo shi yan xue ye xue za zhi
Treatment Used:
Low Dose Combined Chemotherapy (LDCC)
Number of Patients:
9
Published —
August 17, 2019
This study evaluated the clinical effectiveness of low dose combined chemotherapy (LDCC) for patients with relapsed and refractory aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome.
Condition:
Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Compared to Paroxysmal Nocturnal Hemoglobinuria-Aplastic Anemia Syndrome (PNH-AA)
Journal:
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Treatment Used:
Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT)
Number of Patients:
46
Published —
July 26, 2019
This study compared the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for paroxysmal nocturnal hemoglobinuria (PNH) with paroxysmal nocturnal hemoglobinuria-aplastic anemia (PNH-AA) syndrome.
Condition:
Paroxysmal Nocturnal Hemoglobinuria
Journal:
Medicine
Treatment Used:
Eculizamab
Number of Patients:
33
Published —
July 07, 2019
The objective of this study was to assess the procoagulant activity of plasma isolated from paroxysmal nocturnal hemoglobinuria (PNH) patients (treated or not by eculizumab) and to quantify their circulating extracellular vesicles (EVs).
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