Latest Advances

  • Condition: Non-Severe Aplastic Anemia
  • Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • Treatment Used: Cyclosporin A (CsA) with Recombined Human Thrombopoietin (rhTPO)
  • Number of Patients: 83
  • Published —
This study tested the safety and efficacy of using CsA combined with rhTPO to treat patients with non-severe aplastic anemia.
  • Condition: Paroxysmal Nocturnal Hemoglobinuria (PNH) Complicated with Iron Deficiency Anemia
  • Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • Treatment Used: Iron Therapy
  • Number of Patients: 48
  • Published —
This study evaluated the effectiveness and safety of iron supplementation in patients with paroxysmal nocturnal hemoglobinuria (an acquired disorder that leads to the premature death and impaired production of blood cells; PNH) with iron deficiency.
  • Condition: Paroxysmal Nocturnal Hemoglobinuria
  • Journal: PloS one
  • Treatment Used: Ravulizumab or Eculizumab
  • Number of Patients: 98
  • Published —
This study compared the clinical outcome of using ravulizumab or eculizumab to treat patients with paroxysmal nocturnal hemoglobinuria.
  • Condition: Paroxysmal Nocturnal Hemoglobinuria
  • Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology
  • Treatment Used: Eculizumab
  • Number of Patients: 8
  • Published —
This study tested the safety and efficacy of using eculizumab to treat patients with paroxysmal nocturnal hemoglobinuria.
  • Condition: Paroxysmal Nocturnal Hemoglobinuria
  • Journal: Annals of hematology
  • Treatment Used: Eculizumab
  • Number of Patients: 0
  • Published —
In this study, researchers evaluated the outcomes of eculizumab therapy for the treatment of paroxysmal nocturnal hemoglobinuria.
  • Condition: Children With Severe Aplastic Anemia
  • Journal: Zhongguo shi yan xue ye xue za zhi
  • Treatment Used: reduced dose of cyclophosphamide combined cyclosporine A
  • Number of Patients: 10
  • Published —
The purpose of the study was to analyze the clinical efficacy and side effects of reduced-dose of cyclophosphamide combined with cyclosporine A for severe aplastic anemia children.
  • Condition: Paroxysmal Nocturnal Hemoglobinuria (PNH)
  • Journal: Blood
  • Treatment Used: Crovalimab
  • Number of Patients: 29
  • Published —
This study assessed the safety, effectiveness, pharmacokinetics, and pharmacodynamics of C5 inhibitor, crovalimab, in patient with paroxysmal nocturnal hemoglobinuria (rare blood disorder).
  • Condition: Pediatric Hepatic Venous Outflow Tract Obstruction
  • Journal: Indian pediatrics
  • Treatment Used: Angioplasty or Liver Transplantation
  • Number of Patients: 11
  • Published —
This study reviewed case records of children diagnosed with hepatic venous outflow tract obstruction.
  • Condition: Severe Aplastic Anemia
  • Journal: Haematologica
  • Treatment Used: Antithymocyte Globulin and Cyclosporine with or without Granulocyte Colony-stimulating Factor (G-CSF)
  • Number of Patients: 192
  • Published —
In this study, researchers evaluated the outcomes of treating severe aplastic anemia with antithymocyte globulin and cyclosporine, with or without granulocyte colony-stimulating factor (G-CSF).
  • Condition: Relapsed and Refractory Aplastic Anemia-Paroxysmal Nocturnal Hemoglobinuria Syndrome (AA-PNH)
  • Journal: Zhongguo shi yan xue ye xue za zhi
  • Treatment Used: Low Dose Combined Chemotherapy (LDCC)
  • Number of Patients: 9
  • Published —
This study evaluated the clinical effectiveness of low dose combined chemotherapy (LDCC) for patients with relapsed and refractory aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome.
  • Condition: Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Compared to Paroxysmal Nocturnal Hemoglobinuria-Aplastic Anemia Syndrome (PNH-AA)
  • Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • Treatment Used: Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT)
  • Number of Patients: 46
  • Published —
This study compared the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for paroxysmal nocturnal hemoglobinuria (PNH) with paroxysmal nocturnal hemoglobinuria-aplastic anemia (PNH-AA) syndrome.
  • Condition: Paroxysmal Nocturnal Hemoglobinuria
  • Journal: Medicine
  • Treatment Used: Eculizamab
  • Number of Patients: 33
  • Published —
The objective of this study was to assess the procoagulant activity of plasma isolated from paroxysmal nocturnal hemoglobinuria (PNH) patients (treated or not by eculizumab) and to quantify their circulating extracellular vesicles (EVs).
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