Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Primary Objective • To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks among patients treated with Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg once daily. Secondary Objectives * To assess the improvement in reflux symptoms using the GERD-Q score at 8 weeks. * To evaluate the incidence of adverse events across treatment groups.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Adults ≥18 years of age.
• Endoscopically confirmed LA grade B, C, or D reflux esophagitis.
• GERD symptoms (heartburn, regurgitation) for at least 4 weeks prior to enrollment.
• Willing to provide informed consent and comply with study procedures.
Locations
Other Locations
India
Asian Institute of Gastroenterology /Aig Hospitals
RECRUITING
Hyderabad
Contact Information
Primary
Rajesh Goud Mr Maragoni, M.Pharm
rajeshgoud761@gmail.com
04023378888
Backup
Zaheer Dr Nabi, MD DNB
zaheernabi1978@gmail.com
04023378888
Time Frame
Start Date: 2025-06-07
Estimated Completion Date: 2027-12-12
Participants
Target number of participants: 414
Treatments
Other: To determine whether Vonaprazon 10mg heals grade B esophagitis at 8 weeks
Vonaprazon 10 mg heals gerd symptoms after 8 weeks
Other: To determine whether Vonaprazon 20mg heals grade B esophagitis at 8 weeks
Vonaprazon 20 mg heals gerd symptoms after 8 weeks
Other: To determine whether esomeprazole 40mg heals grade B esophagitis at 8 weeks
Esomeprazole 40mg heals gerd symptoms after 8 weeks
Related Therapeutic Areas
Sponsors
Leads: Asian Institute of Gastroenterology, India