Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Objective: • To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks in patients receiving Vonaprazan 20 mg versus Esomeprazole 40 mg. Secondary Objectives * To assess improvement in reflux symptoms using the GERD-Q score at 8 weeks. * To evaluate the incidence of adverse events in each treatment group.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age ≥18 years
• History of POEM for achalasia
• Endoscopic confirmation of LA grade B, C, or D reflux esophagitis at 3 months post-POEM
• GERD symptoms (heartburn, regurgitation) for ≥4 weeks
• Willingness to provide informed consent and comply with study procedures
Locations
Other Locations
India
Asian Institute of Gastroenterology /Aig Hospitals
RECRUITING
Hyderabad
Contact Information
Primary
Rajesh Goud Mr Maragoni, M.Pharm
rajeshgoud761@gmail.com
04023378888
Backup
Zaheer Nabi Dr Mohammed, MD DNB
zaheernabi1978@gmail.com
04023378888
Time Frame
Start Date: 2025-04-30
Estimated Completion Date: 2028-12-25
Participants
Target number of participants: 300
Treatments
Active_comparator: To assess the efficacy of vonapraprazon 20mg better than esomeprazole drug
healing rate will be checked during endoscopy at 8 weeks
Placebo_comparator: To see the healing rate of grade B esophagitis
healing rate will be checked during endoscopy at 8 weeks in patients receiving esomeprazole 40mg
Related Therapeutic Areas
Sponsors
Leads: Asian Institute of Gastroenterology, India