What is the definition of Peripartum Cardiomyopathy?

Peripartum cardiomyopathy is a rare disorder in which a pregnant woman's heart becomes weakened and enlarged. It develops during the last month of pregnancy, or within 5 months after the baby is born.

What are the alternative names for Peripartum Cardiomyopathy?

Cardiomyopathy - peripartum; Cardiomyopathy - pregnancy

What are the causes for Peripartum Cardiomyopathy?

Cardiomyopathy occurs when there is damage to the heart. As a result, the heart muscle becomes weak and does not pump well. This affects the lungs, liver, and other body systems.

Peripartum cardiomyopathy is a form of dilated cardiomyopathy in which no other cause of heart weakening can be found.

It may occur in childbearing women of any age, but it is most common after age 30.

Risk factors for the condition include:

  • Obesity
  • Personal history of cardiac disorders such as myocarditis
  • Use of certain medicines
  • Smoking
  • Alcoholism
  • Multiple pregnancies
  • Old age
  • Preecclampsia
  • African American descent
  • Poor nourishment

What are the symptoms for Peripartum Cardiomyopathy?

Symptoms may include:

  • Fatigue
  • Feeling of heart racing or skipping beats (palpitations)
  • Increased nighttime urination (nocturia)
  • Shortness of breath with activity and when lying flat
  • Swelling of the ankles

What are the current treatments for Peripartum Cardiomyopathy?

A woman may need to stay in the hospital until acute symptoms subside.

Because it is very often possible to restore heart function, and the women who have this condition are often young and otherwise healthy, care is often aggressive.

When severe symptoms occur, this may include extreme steps such as:

  • Use of an assistive heart pump (aortic counterpulsation balloon, left ventricular assist device)
  • Immunosuppressive therapy (such as medicines used to treat cancer or prevent rejection of a transplanted organ)
  • Heart transplant if severe congestive heart failure persists

For most women, however, treatment mainly focuses on relieving the symptoms. Some symptoms go away on their own without treatment.

Medicines that are often used include:

  • Digitalis to strengthen the heart's pumping ability
  • Diuretics ("water pills") to remove excess fluid
  • Low-dose beta-blockers
  • Other blood pressure medicines

A low-salt diet may be recommended. Fluid may be restricted in some cases. Activities, including nursing the baby, may be limited when symptoms develop.

Daily weighing may be recommended. A weight gain of 3 to 4 pounds (1.5 to 2 kilograms) or more over 1 or 2 days may be a sign of fluid buildup.

Women who smoke and drink alcohol will be advised to stop, since these habits may make the symptoms worse.

What is the outlook (prognosis) for Peripartum Cardiomyopathy?

There are several possible outcomes in peripartum cardiomyopathy. Some women remain stable for long periods, while others get worse slowly.

Others get worse very quickly and may be candidates for a heart transplant. About 4% of people will require heart transplantation and 9% may die suddenly or die from complications of the procedure.

The outlook is good when a woman's heart returns to normal after the baby is born. If the heart remains abnormal, future pregnancies may result in heart failure. It is not known how to predict who will recover and who will develop severe heart failure. Up to about one half of women will recover completely.

Women who develop peripartum cardiomyopathy are at high risk of developing the same problem with future pregnancies. The rate of recurrence is about 30%. Therefore, women who have had this condition should discuss birth control methods with their provider.

What are the possible complications for Peripartum Cardiomyopathy?

Complications include:

  • Cardiac arrhythmias (can be deadly)
  • Congestive heart failure
  • Clot formation in the heart which can embolize (travel to other parts of the body)

When should I contact a medical professional for Peripartum Cardiomyopathy?

Call your provider if you are currently pregnant or have recently delivered a baby and think you may have signs of cardiomyopathy.

Get medical help right away if you develop chest pain, palpitations, faintness, or other new or unexplained symptoms.

How do I prevent Peripartum Cardiomyopathy?

Eat a well-balanced diet and get regular exercise to help keep your heart strong. Avoid cigarettes and alcohol. Your provider may advise you to avoid getting pregnant again if you have had heart failure during a previous pregnancy.

Heart - section through the middle
Heart - front view

REFERENCES

Blanchard DG, Daniels LB. Cardiac diseases. In: Resnik R, Lockwood CJ, Moore TR, Greene MF, Copel JA, Silver RM, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 52.

McKenna WJ, Elliott PM. Diseases of the myocardium and endocardium. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 54.

Silversides CK, Warnes CA. Pregnancy and heart disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 90.

  • Journal: Zhonghua wei zhong bing ji jiu yi xue
  • Published —
Application of extracorporeal membrane oxygenation in critically ill pregnant women.
  • Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
  • Published —
Cardiovascular magnetic resonance in women with cardiovascular disease: position statement from the Society for Cardiovascular Magnetic Resonance (SCMR).
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 3
  • Intervention Type: Other, Drug
  • Participants: 80
  • Start Date: January 1, 2017
Bromocriptine in the Treatment of Peripartum Cardiomyopathy, A Bayesian Randomized Registry Trial
Clinical Trial
  • Status: Recruiting
  • Participants: 45
  • Start Date: February 20, 2021
FDNC5 Genetic Polymorphism in Patients With Peripartum Cardiomyopathy