Progressive Elaboration Framework of Mortality in Treated and Controlled Hypertension: A Pooled Analysis of Contributing Factors to Silent or Uncontrollable Fatal Syndromes
This pooled analysis investigates death outcomes in patients with pharmacologically treated and blood pressure-controlled hypertension. Despite documented BP control, some patients still suffer fatal cardiovascular, cerebrovascular, renal, or unexplained syndromes. This study aims to synthesize available evidence across study types to identify treatment pitfalls, contributing syndromes, and non-BP factors associated with these fatal outcomes.
• Human studies (RCTs, cohort, case-control, registry studies, etc.) declare participants with treated and controlled hypertension manage (regardless of drug class, duration, or comorbidity) reported mortality outcomes: all-vascular death, cardiovascular death, sudden death, etc.
• Studies in any setting (outpatient, inpatient, long-term follow-up)
• Articles in English
• Full-text available