Preeclampsia And Nonsteroidal Drugs for Analgesia (PANDA): a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on postpartum hypertension.
• Women at \> 23 weeks gestational age undergoing vaginal or cesarean delivery at Barnes-Jewish Hospital with:
• An antepartum diagnosis of preeclampsia with severe features
• Pre-eclampsia with severe features will be defined as:
• Elevated blood pressure ≥ 160/110, or
• Pre-eclampsia in the setting of thrombocytopenia (platelet count \< 100,000), or
• Impaired liver function (AST elevated to twice upper limit of normal), or
• Persistent epigastric pain, or
• Renal insufficiency (serum creatinine of 1.1 mg/dl or doubling of prior value), or
• Pulmonary edema, or
• New onset visual disturbance or headache unresponsive to therapy.