To Establish Whether Individuals With Premenstrual Dysphoric Disorder (PMDD) Demonstrate a Different Luteal-phase Sex Hormone Profile and Ratio Compared With Asymptomatic Controls.
The aim of this project is to compare the ovarian hormone levels 7 days after ovulation and progesterone:oestradiol ratios between PMDD individuals and a control cohort (case control study).
• Aged 18-45 years old (adults but less than the typical perimenopausal age so there is not added bias/variable)
• Regular menstrual cycles (21-35 days for the last 3 months)
• Willing and able to complete a questionnaire (no new clinical diagnosis given)
• Use home urine LH test strips to detect ovulation
• Attend a single in person on site in Lancaster mid luteal blood test sample appointment (approx 7 days post LH surge)
• Provide written informed consent
• Have sufficient English language skills to understand the patient information
• Be either in Group 1 or group 2 Group 1 (PMDD group ie case group) - self reported prior diagnosis of PMDD made by a healthcare professional (GP, psychiatrist, gynaecologist) Group 2 (Control group ie comparison group) - no prior diagnosis of PMDD made by a healthcare professional and no history of clinically significant premenstrual mood symptoms on screening