Primary Lateral Sclerosis Latest Advances

Development of a machine learning-based survival prediction model for ALS inclusive of the advanced-stage population.

Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration

Published: April 13, 2026

Discovery of a novel TFEB activator targeting lysosomal dysfunction in amyotrophic lateral sclerosis using artificial intelligence-based virtual screening.

Journal: Autophagy

Published: April 13, 2026

Primary lateral sclerosis in Brazil: phenotypic heterogeneity, non-motor features, and prognostic markers in a 17-year multicentre cohort.

Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration

Published: April 13, 2026

Out-of-Pocket Cost of Spinal Muscular Atrophy Gene Therapies Among Commercially Insured Patients.

Journal: JAMA pediatrics

Published: April 13, 2026

Fast and controlled access to tofersen for SOD1-related amyotrophic lateral sclerosis in The Netherlands; experiences using the orphan drug access protocol.

Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration

Published: April 13, 2026

Disappearing corticospinal tract on routine MRI: dynamic signal evolution in primary lateral sclerosis.

Journal: BMJ case reports

Published: April 08, 2026

Navigating new motor function trajectories: Consensus recommendations for assessment in the era of newborn screening and early treatment in SMA.

Journal: Journal of neuromuscular diseases

Published: April 07, 2026

Incidence, Timing and Clinical Significance of Immune-Mediated Myocardial Injury and Myocarditis After Gene Replacement Therapy: A Systematic Review and Meta-Analysis.

Journal: Circulation. Heart failure

Published: April 07, 2026

Cross-disease genetic and epigenetic architecture of the MOBP locus shows convergence in ALS-PSP.

Journal: bioRxiv : the preprint server for biology

Published: April 03, 2026

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis.

Journal: bioRxiv : the preprint server for biology

Published: April 03, 2026

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophy.

Journal: bioRxiv : the preprint server for biology

Published: April 03, 2026

Longitudinal Analysis of Superoxide Dismutase 1 Seeding Activity in Amyotrophic Lateral Sclerosis Cerebrospinal Fluid.

Journal: medRxiv : the preprint server for health sciences

Published: April 03, 2026

Primary Lateral Sclerosis Latest Advances

Find the Latest Research About Primary Lateral Sclerosis

Development of a machine learning-based survival prediction model for ALS inclusive of the advanced-stage population.

Development of a machine learning-based survival prediction model for ALS inclusive of the advanced-stage population.

Discovery of a novel TFEB activator targeting lysosomal dysfunction in amyotrophic lateral sclerosis using artificial intelligence-based virtual screening.

Discovery of a novel TFEB activator targeting lysosomal dysfunction in amyotrophic lateral sclerosis using artificial intelligence-based virtual screening.

Primary lateral sclerosis in Brazil: phenotypic heterogeneity, non-motor features, and prognostic markers in a 17-year multicentre cohort.

Primary lateral sclerosis in Brazil: phenotypic heterogeneity, non-motor features, and prognostic markers in a 17-year multicentre cohort.

Out-of-Pocket Cost of Spinal Muscular Atrophy Gene Therapies Among Commercially Insured Patients.

Out-of-Pocket Cost of Spinal Muscular Atrophy Gene Therapies Among Commercially Insured Patients.

Fast and controlled access to tofersen for SOD1-related amyotrophic lateral sclerosis in The Netherlands; experiences using the orphan drug access protocol.

Fast and controlled access to tofersen for SOD1-related amyotrophic lateral sclerosis in The Netherlands; experiences using the orphan drug access protocol.

Disappearing corticospinal tract on routine MRI: dynamic signal evolution in primary lateral sclerosis.

Disappearing corticospinal tract on routine MRI: dynamic signal evolution in primary lateral sclerosis.

Navigating new motor function trajectories: Consensus recommendations for assessment in the era of newborn screening and early treatment in SMA.

Navigating new motor function trajectories: Consensus recommendations for assessment in the era of newborn screening and early treatment in SMA.

Incidence, Timing and Clinical Significance of Immune-Mediated Myocardial Injury and Myocarditis After Gene Replacement Therapy: A Systematic Review and Meta-Analysis.

Incidence, Timing and Clinical Significance of Immune-Mediated Myocardial Injury and Myocarditis After Gene Replacement Therapy: A Systematic Review and Meta-Analysis.

Cross-disease genetic and epigenetic architecture of the MOBP locus shows convergence in ALS-PSP.

Cross-disease genetic and epigenetic architecture of the MOBP locus shows convergence in ALS-PSP.

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis.

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis.

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophy.

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophy.

Longitudinal Analysis of Superoxide Dismutase 1 Seeding Activity in Amyotrophic Lateral Sclerosis Cerebrospinal Fluid.

Longitudinal Analysis of Superoxide Dismutase 1 Seeding Activity in Amyotrophic Lateral Sclerosis Cerebrospinal Fluid.