Pure Red Cell Aplasia Overview

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Learn About Pure Red Cell Aplasia

What is the definition of Pure Red Cell Aplasia?
Pure red cell aplasia (PRCA) is a rare condition that affects the bone marrow. Bone marrow contains stem cells which develop into the red blood cells that carry oxygen through the body, the white blood cells that fight infections, and the platelets that help with blood clotting. In people with PRCA, the bone marrow makes a reduced number of red blood cells (called anemia). As a result, affected people may experience fatigue, lethargy, and pale skin. PRCA has many different causes. A rare congenital form of PRCA, called Diamond Blackfan syndrome, is an inherited condition that is also associated with other physical abnormalities. PRCA can also be due to certain medications, infections, pregnancy, renal failure, and conditions such as thymomas, autoimmune disease (such as systemic lupus erythematosus), cancers of the blood, and solid tumors. In many cases, the cause of the condition is unknown (idiopathic).
What are the alternative names for Pure Red Cell Aplasia?
  • Pure red cell aplasia
  • PRCA
Who are the top Pure Red Cell Aplasia Local Doctors?
Elite in Pure Red Cell Aplasia
Dr. Kathleen M. Sakamoto
Pediatric Hematology Oncology
Elite in Pure Red Cell Aplasia
Dr. Kathleen M. Sakamoto
Pediatric Hematology Oncology

Lpch Medical Group Div Of Lucile

725 Welch Rd, 
Palo Alto, CA 
650-498-7200
Languages Spoken:
English
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Kathleen Sakamoto is a Pediatric Hematologist Oncology provider in Palo Alto, California. Dr. Sakamoto is rated as an Elite provider by MediFind in the treatment of Pure Red Cell Aplasia. Her top areas of expertise are Aase Syndrome, Pure Red Cell Aplasia, Transient Erythroblastopenia of Childhood, Aplastic Anemia, and Bone Marrow Aspiration.

Jeffrey H. Lipton
Elite in Pure Red Cell Aplasia
Jeffrey H. Lipton
Elite in Pure Red Cell Aplasia
Jeffrey H. Lipton
55 Harbord St, M5S 2 W6, 
Toronto, ON, CA 

Jeffrey Lipton practices in Toronto, Canada. Mr. Lipton is rated as an Elite expert by MediFind in the treatment of Pure Red Cell Aplasia. His top areas of expertise are Chronic Myelogenous Leukemia (CML), Leukemia, Pure Red Cell Aplasia, Aase Syndrome, and Bone Marrow Transplant.

 
 
 
 
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Jaroslaw Maciejewski
Elite in Pure Red Cell Aplasia
Dr. Jaroslaw Maciejewski
Hematology
Elite in Pure Red Cell Aplasia
Dr. Jaroslaw Maciejewski
Hematology

Cleveland Clinic Main Campus

10201 Carnegie Avenue, 
Cleveland, OH 
866-223-8100
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Jaroslaw Maciejewski is a Hematologist in Cleveland, Ohio. Dr. Maciejewski is rated as an Elite provider by MediFind in the treatment of Pure Red Cell Aplasia. His top areas of expertise are Paroxysmal Nocturnal Hemoglobinuria (PNH), Aplastic Anemia, Paroxysmal Cold Hemoglobinuria, Bone Marrow Transplant, and Splenectomy.

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What are the latest Pure Red Cell Aplasia Clinical Trials?
Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History Study
Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History Study
Enrollment Status: Recruiting
Publish Date: October 14, 2025

Background: A prospective cohort of Inherited Bone Marrow Failure Syndrome (IBMFS) will provide new information regarding cancer rates and types in these disorders. Pathogenic variant(s) in IBMFS genes are relevant to carcinogenesis in sporadic cancers. Patients with IBMFS who develop cancer differ in their genetic and/or environmental features from patients with IBMFS who do not develop cancer. These cancer-...

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Sickle Cell Disease Transplant Using a Nonmyeloablative Approach: Adding Daratumumab for Patients With Anti-donor Red Cell AntibodY
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach: Adding Daratumumab for Patients With Anti-donor Red Cell AntibodY
Enrollment Status: Recruiting
Publish Date: September 26, 2025
Intervention Type: Drug, Radiation
Study Phase: Phase 2

Summary: This multicenter prospective study seeks to determine if daratumumab given, prior to HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus, can prevent pure red blood cell aplasia with an acceptable safety profile in patients with anti-donor red blood cell antibodies, achieving an event-free survival similar to transplanted patients without s...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center