Safety and Efficacy of Zanubrutinib in the Treatment of Immune Thrombocytopenia
To evaluate the safety and efficacy of zanubrutinib in the treatment of immune thrombocytopenia in 30 patients.
• Age 18 and above, male or female；
• Conform to the diagnostic criteria of immune Thrombocytopenia (ITP)；
• Diagnosis of ITP\>3 months；
• Primary ITP with a platelet count of \<30 X 109/L prior to inclusion with failure to achieve response or relapse after corticosteroid therapy, and at least one second-line therapy including rituximab \>12 weeks ago and/or TPO-RAs.
• Liver and kidney function, such as ALT, AST, BUN, SCR \< 1.5 × upper limit of normal value, passing physical examination;
• ECOG physical state score ≤ 2 points；
• Cardiac function of the New York Society of Cardiac Function ≤ 2；
• Signed and dated written informed consent.