• Age 18-60 years (inclusive) at the time of signing Informed Consent Form

• Diagnosis of progressive MS according to the revised McDonald 2017 criteria, and:

⁃ Expanded disability status scale (EDSS) score at screening, from 3 to 6 inclusive Evidence of disability progression and no relapses in the 2 years prior to screening

⁃ \- Diagnosis of relapsing MS according to the revised McDonald 2017 criteria, and: Evidence of clinical relapses and MRI activity within two years prior to screening while on a disease modifying therapy

• EDSS score at screening, from 0 to 6 inclusive

• No relapses within 45 days of screening