Effect of Methotrexate Discontinuation on Immunogenicity of Shingrix in Patients With Rheumatoid Arthritis

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if methotrexate discontinuation affect on immunogeneity of shingrix in RA patients. The main questions it aims to answer are: Discontinuation of methotrexate after shingrix immunization increase efficacy of the vaccine in patients with RA ? Researchers will compare humoral and cell-mediated immunity against herpes zoster in RA patients who are vaccinated by shingrix, and compare these immunity between RA patients with MTX discontinuation and MTX continuation groups. Participants will: Vaccinated with shingrix twice. MTX continuation group will keep taking MTX after shingrix vaccination, whereas MTX discontinuation group will stop MTX for 2 weeks after shingrix vaccination. Visit the clinic at baseline (first shingrix vaccination), 2 months later for 2nd shingrix vaccination, then 3 \& 6 months later from baseline to achieve blood sample.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Healthy Volunteers: f
View:

• fulfill 2010 ACR/EULAR classification criteria for rheumatoid arthritis

• age over 19 years

• methotrexate user

• agree for vaccination with shingrix

Locations
Other Locations
Republic of Korea
Konkuk University Medical Center
RECRUITING
Seoul
Contact Information
Primary
Hong Ki Min, MD, PhD
alsghdrl1921@naver.com
+82-10-9977-5455
Time Frame
Start Date: 2024-08-22
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 110
Treatments
Experimental: MTX discontinuation
methotrexate stop for 2 weeks after each shingrix vaccination
Active_comparator: MTX continuation
Sponsors
Leads: Konkuk University Medical Center

This content was sourced from clinicaltrials.gov