Rheumatoid Arthritis (RA) Clinical Trials

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Evaluation of the Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Dietary supplement, Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are: * Is supplementation with vitamin E (α-tocopherol) for one month associated with decreased clinical activity and inflammation in patients with RA? Researchers will compare α-tocopherol with a placebo (a look-alike substance containing no active ingredient) to see if α-tocopherol effectively reduces inflammation and clinical activity in patients with rheumatoid arthritis. Participants will: * Take two capsules (one in the morning and one in the afternoon) of either α-tocopherol or placebo every day for a month. * Attend clinic visits at the start of the intervention (baseline) and at the end of the month for final check-ups and tests. * Keep a diary to record your symptoms and how often you take α-tocopherol or placebo.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Female sex

• RA classification (ACR/EULAR 2010)

• Early RA 2 years

• Treatment with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations)

• DAS28 ≥3.2

• Vitamin E intake deficiency (\<15mg/day)

• No comorbidities

• Age \> 18 years

• Voluntary participation and informed consent.

Locations
Other Locations
Mexico
Civil Hospital of Guadalajara
RECRUITING
Guadalajara
Universidad de Guadalajara
NOT_YET_RECRUITING
Guadalajara
Contact Information
Primary
Christian Johana J Baños Hernández, D.Sc.
johana.banos@academicos.udg.mx
+54 10585200 ó 7471493487
Backup
Martin De Leon Cid, B.Nutr.
martin.deleon9901@alumnos.udg.mx
+54 4931817830
Time Frame
Start Date: 2026-02-06
Estimated Completion Date: 2027-01-15
Participants
Target number of participants: 46
Treatments
Active_comparator: Intervention group
Treated with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations) plus vitamin E 800mg/day.
Placebo_comparator: Control group
Treated with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations) plus the consumption of magnesium oxide 200mg/day in placebo form.
Related Therapeutic Areas
Sponsors
Leads: University of Guadalajara
Collaborators: Hospital Civil de Guadalajara

This content was sourced from clinicaltrials.gov