Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g. clinical features, genetic variants, and/or biologic markers) between other forms of ILD (e.g. idiopathic pulmonary fibrosis, IPF) and subclinical RA-ILD that places individuals at risk for the development of lung disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 90
Healthy Volunteers: f
View:
• ≥ 45years old
• Diagnosis of RA using the 2010 American College of Rheumatology (ACR) criteria
Locations
United States
Colorado
University of Colorado - Anschutz Medical Campus
RECRUITING
Aurora
Contact Information
Primary
Haylie A Lengel
haylie.lengel@cuanschutz.edu
970-376-8303
Backup
Joyce S Lee, MD
joyce.lee@ucdenver.edu
303-724-6109
Time Frame
Start Date: 2017-06-22
Estimated Completion Date: 2027-06
Participants
Target number of participants: 750
Treatments
RA with Sub-clinical ILD
Subjects will be followed annually until study closure.~Assessments are as follows:~1. Clinical (Annual): Demographics, health-related behaviors, co-morbidities, medications, respiratory symptoms, rheumatologic assessment, quality of life~2. Physiologic (3-5 yrs FU): Lung function on Pulmonary Function Test (PFT)~3. Radiologic (3-5 yrs FU): HRCT scan of chest~4. Genetic (3-5 yrs FU): Blood sample collection for RNA~5. Biologic (3-5 yrs FU): Blood sample collection for other blood markers
RA with No-ILD
Subjects will be followed annually until study closure.~Assessments are as follows:~1. Clinical (Annual): Demographics, health-related behaviors, co-morbidities, medications, respiratory symptoms, rheumatologic assessment, quality of life~2. Physiologic (3-5 yrs FU): Lung function on Pulmonary Function Test (PFT)~3. Radiologic (3-5 yrs FU): HRCT scan of chest~4. Genetic (3-5 yrs FU): Blood sample collection for RNA~5. Biologic (3-5 yrs FU): Blood sample collection for other blood markers~Note: Certain follow-up procedures may not occur for every subject and will be determined by the research team.
Authors
Aryeh Fischer
Related Therapeutic Areas
Sponsors
Leads: University of Colorado, Denver