Radiologic Features of Patients With Rheumatoid Arthritis Related Interstitial Lung Disease at Chest High Resolution Computed Tomography

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Lung involvement is one of the most frequent extra articular involvements of rheumatoid arthritis (RA). RA related lung involvement can affect parenchyma, airway, vascular tree and serosa. Among all possible manifestations of lung disease, interstitial lung disease is the most severe being able to compromise quality of life and survival and involves about 20% of patients with rheumatoid arthritis (RA). However, chest high resolution computed tomography (HRCT) features of RA, with or without interstitial lung involvement, have not been clearly defined. Such features have been mostly investigated on small populations of RA patients, often including patients with connective tissue diseases (CTDs), namely systemic sclerosis, mixed connective tissue disease, idiopathic inflammatory myopathies, making difficult to discriminate possible specific features of RA interstitial lung disease (ILD). The aims of this observational longitudinal study are to investigate: i) chest HRCT features of RA (frequency of radiologic HRCT patterns, fibrosis, nodules, bronchiectasis, etc.), associated or not to ILD; ii) possible associations between chest HRCT features and demographic, clinical and serologic characteristics of RA; iii) specific chest HRCT features of RA ILD, compared to idiopathic pulmonary fibrosis (IPF) and CTD ILD (i.e., primary Sjogren syndrome, idiopathic inflammatory myopathies, etc), according to the Centres availability. Consecutive, unselected, DICOM files of chest HRCT of adult RA patients (regardless a previous diagnosis of ILD) will be evaluated by an expert thoracic radiologist blinded to patients' clinical history. HRCT patterns, presence of fibrosis and other lung abnormalities (cysts, nodules, pleural effusion, etc) will be recorded. In patients with RA ILD possible associations with demographic and clinical disease features will be also analysed (such as sex, disease duration, disease duration at ILD diagnosis, presence of ACPA, rheumatoid factor, ANA), inclusion of previous therapies. After 2 years, new HRCT and lung function tests will be collected for each enrolled patients when available, to evaluate possible changes of lung involvement over time.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• patients able to give their informed consent

• at least aged 18 years

• patients undergoing High-Resolution Computed Tomography (HRCT) for clinical needs at any point in their medical history

• patients with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis or connective tissue disease

Locations
Other Locations
Italy
UOC Reumatologia, Arcipedale Sant'Anna
RECRUITING
Ferrara
SC Malattie Apparato Respiratorio, Azienda Policlinico di Modena
RECRUITING
Modena
Local Health Unit (Azienda Unità Sanitaria Locale, AUSL) of Piacenza
RECRUITING
Piacenza
AUSL-IRCCS di Reggio Emilia
RECRUITING
Reggio Emilia
Contact Information
Primary
Marco Sebastiani, MD
m.sebastiani@ausl.pc.it
+39 0523302645
Backup
Francesca Cozzini, M.D.
f.cozzini@ausl.pc.it
+39 0523302645
Time Frame
Start Date: 2025-01-08
Estimated Completion Date: 2035-01
Participants
Target number of participants: 500
Treatments
Rheumatoid arthritis-interstitial lung disease group
Patients with rheumatoid arthritis related interstitial lung disease undergoing to HRCT at any time of their clinical history
Idiopathic pulmonary fibrosis
Patients with idiopathic pulmonary fibrosis underoging to HRCT at any time of their clincial history
Connective tissue disease - interstitial lung disease
Patients with connective tissue diseases related interstitial lung disease undergoing to HRCT at any time of their clinical history
Sponsors
Leads: Azienda Unita Sanitaria Locale di Piacenza
Collaborators: University of Parma

This content was sourced from clinicaltrials.gov