View Main Condition: Short Stature (Growth Disorders)
Russell-Silver syndrome is a growth disorder characterized by slow growth before and after birth. Babies with this condition have a low birth weight and often fail to grow and gain weight at the expected rate (failure to thrive). Head growth is normal, however, so the head may appear unusually large compared to the rest of the body. Affected children are thin and have poor appetites, and some develop recurrent episodes of low blood sugar (hypoglycemia) as a result of feeding difficulties. Adults with Russell-Silver syndrome are short; the average height for affected men is about 151 centimeters (4 feet, 11 inches) and the average height for affected women is about 140 centimeters (4 feet, 7 inches).
The genetic causes of Russell-Silver syndrome are complex. The disorder often results from the abnormal regulation of certain genes that control growth. Research has focused on genes located in particular regions of chromosome 7 and chromosome 11.
The exact incidence of Russell-Silver syndrome is unknown. Worldwide estimates range from 1 in 30,000 to 1 in 100,000 people.
Most cases of Russell-Silver syndrome are sporadic, which means they occur in people with no history of the disorder in their family.
Irene Netchine practices in Paris, France. Netchine is rated as an Elite expert by MediFind in the treatment of Russell-Silver Dwarfism. She is also highly rated in 21 other conditions, according to our data. Her top areas of expertise are Russell-Silver Dwarfism, Beckwith-Wiedemann Syndrome, Macroglossia, and Short Stature (Growth Disorders).
Thomas Eggermann practices in Aachen, Germany. Eggermann is rated as an Elite expert by MediFind in the treatment of Russell-Silver Dwarfism. He is also highly rated in 34 other conditions, according to our data. His top areas of expertise are Russell-Silver Dwarfism, Beckwith-Wiedemann Syndrome, Macroglossia, and Transient Neonatal Diabetes Mellitus.
Gerhard Binder practices in Tübingen, Germany. Binder is rated as an Elite expert by MediFind in the treatment of Russell-Silver Dwarfism. He is also highly rated in 33 other conditions, according to our data. His top areas of expertise are Russell-Silver Dwarfism, Short Stature (Growth Disorders), Growth Hormone Deficiency (GHD), Turner Syndrome, and Hormone Replacement Therapy (HRT).
Summary: CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, in...
Summary: This study is a multi-center, retrospective and non-interventional research. In this study, a total of 150 short children who were small for gestational age and had been treated with recombinant human growth hormone (rhGH) are selected for genetic testing. The aims of this study are to analyze the genetic etiology of SGA children with short stature, and to compare the efficacy and safety of rhGH t...
Published Date: September 01, 2016Published By: National Institutes of Health