Induction of Gut Permeability by an Oral Vaccine
Who is this study for? Adult female patients with Typhoid Fever
What treatments are being studied? Vivotif Typhoid Vaccine
Status: Active_not_recruiting
Location: See location...
Intervention Type: Drug, Biological
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system. Intestinal and whole-body responses will be measured in all participants before and after the vaccine.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 49
Healthy Volunteers: t
View:
• Body Mass Index (BMI) 18.5 - 29.9 kg/m2
Locations
United States
California
USDA, ARS, Western Human Nutrition Research Center
Davis
Time Frame
Start Date: 2019-12-04
Completion Date: 2026-09-30
Participants
Target number of participants: 10
Treatments
Experimental: Single group
All participants will receive the vaccine and aspirin.
Related Therapeutic Areas
Sponsors
Leads: USDA, Western Human Nutrition Research Center