Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. Our overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

• between ages of 18 and 50

• ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks

• ability to give valid informed consent

Locations
United States
California
Imaging Research Center
RECRUITING
Sacramento
Contact Information
Primary
Minhtrang Chu
mihchu@ucdavis.edu
1-916-734-1482
Time Frame
Start Date: 2021-04-14
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 75
Treatments
Experimental: DLPFC Stimulation
Intervention. 20 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex.
Experimental: Occipital Stimulation
Intervention. 20 minutes of 2 mA direct current stimulation over the occipital cortex.
Sham_comparator: Sham Stimulation
Placebo Comparator. 0.5-1 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex followed by 19-19.5 minutes of sham stimulation
Related Therapeutic Areas
Sponsors
Leads: University of California, Davis

This content was sourced from clinicaltrials.gov