Sensory Contributions to Third Visual Pathway Dysfunction in Schizophrenia: Correlation and Causation
This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability. tDCS is a type of non-invasive brain stimulation in which low level currents are applied over the scalp to influence underlying brain function. In schizophrenia, impaired ability to detect facial motion has been shown to contribute to impaired FER, which, in turn, leads to difficulties in social cognition and poor social outcome. The study will use both fMRI and EEG to measure brain function while participants view moving dot and dynamic face stimuli. Analyses will compare changes in fMRI and EEG activity in individuals receiving active vs. sham stimulation.
• Male or female subject, age 18-55
• Competent and willing to sign informed consent
• No more than moderately ill
• SCID DSM-5 diagnosis of Sz/SzAff
• WAIS IQ \>70
• Does not meet current criteria for DSM-5 defined substance abuse or dependence or have a history of diagnosis within past 6 months
• On medication within clinically approved range
• Does not meet criteria for another DSM-5 disorder other than those judged to be minor (e.g. simple phobia)