MONITORING OF REALITY AND DOPAMINE: A PHARMACOLOGICAL RESEARCH
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease. The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:
• Healthy volunteers who have given their written informed consent
• Men and women from 18 to 45 years old
• Normal or corrected vision
• Being fluent in French or French for native language
• Being affiliated with health insurance
Locations
Other Locations
France
Centre Hospitalier le Vinatier
RECRUITING
Bron
Contact Information
Primary
JEROME BRUNELIN
jerome.brunelin@ch-le-vinatier.fr
0033437915565
Backup
VERONIQUE VIAL
veronique.vial@ch-le-vinatier.fr
0033437915522
Time Frame
Start Date: 2024-01-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 39
Treatments
Active_comparator: Dopamine precursor
In the first condition, volunteers will receive a dopamine (DA) precursor (L-dopa, 100mg). L-dopa will be combined with a dose of an Aromatic amino acid decarboxylase inhibitor (Benserazide) 25mg to multiplicate its bioavailability and with a dose of domperidone 10mg (peripheral antagonist of DA) to minimize the risk of side effects.
Active_comparator: D2 antagonist
In the second condition, volunteers will receive a D2 antagonist (Sulpiride, 800mg)
Placebo_comparator: PLACEBO
In the third condition, volunteers will receive a placebo (lactose)
Related Therapeutic Areas
Sponsors
Leads: Hôpital le Vinatier