Accelerated Neuromodulation of Prefrontal Circuitry During Clozapine Treatment
In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that accelerated iTBS will enhance neurocognition relative to sham delivery.
• A current Diagnostic and Statistical Manual of Mental Disorders 5 (DSM 5)-defined diagnosis of schizophrenia or schizoaffective disorder
• age 18-50 years
• at least 4 months of clozapine treatment
• history of at least 2 failed antipsychotic trials
• competency and willingness to sign informed consent
• A clinically optimized dosage of clozapine, unchanged for at least 1 month, with a minimum of 150 mg/day