Effectiveness of Navigated Transcranial Magnetic Stimulation (nTMS) of Left Supramarginal Gyrus for Negative Symptoms : A Double-blind, Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This research aims to test the effectiveness of Navigated transcranial magnetic stimulation (nTMS) of left Supramarginal Gyrus for negative symptoms. In this double-blind, randomized controlled trial, patients will be assigned to active iTBS experimental group or sham iTBS group. Treatment will last for 10 days, and data will be collected at baseline, 1 day and 1 month after treatment.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 60
Healthy Volunteers: f
View:
• 1.Clinical diagnosis of schizophrenia according to ICD-11.
• 2.Confirmation of the diagnosis of schizophrenia using the SCID-5-RV (DSM-5 Structured Clinical Interview for DSM-5 Disorders - Research Version).
• 3.Score more than 4 points on either item of negative symptoms (N1-N7).
• 4.Aged less than 60 years.
Locations
Other Locations
China
Mental Health Institute of Second Xiangya Hospital,CSU
RECRUITING
Changsha
Contact Information
Primary
Renrong Wu, M.D., Ph.D.
wurenrong2013@163.com
15874179855
Time Frame
Start Date: 2024-11-22
Estimated Completion Date: 2026-03
Participants
Target number of participants: 40
Treatments
Experimental: experimental group: active iTBS
Patients assigned to experimental group would receive treatment of active iTBS. 50 iTBS sessions (1,800 pulses per session, 50-minute intersession interval) were delivered 10 days at 90% resting motor threshold.
Sham_comparator: control group: sham iTBS
Patients assigned to control group would receive treatment of sham iTBS. The iTBS mode in sham iTBS is as the same as the active iTBS, but would be delivered with the sham coil, which provides the sensation of TBS without enough magnetic energy to reach the cortex.
Related Therapeutic Areas
Sponsors
Leads: Central South University