The Effects of Auditory Stimulation During Sleep on Offline Learning and Thalamocortical-hippocampal Connectivity in Schizophrenia

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

• 18-45 years old

• Fluent in English

• Able to give informed consent

⁃ Additional inclusion for Adults with schizophrenia:

• A DSM-V confirmed diagnosis of schizophrenia

• Unmedicated or maintained on a stable dose of APDs

Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Charlestown
Contact Information
Primary
Lindsey Jones, MS
manoachlab@gmail.com
617-702-2368
Backup
Dara Manoach, PhD
dara.manoach@mgh.harvard.edu
617-724-6148
Time Frame
Start Date: 2025-02-05
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 60
Treatments
Experimental: Schizophrenia
Adult outpatients with a diagnosis of schizophrenia.
Active_comparator: Healthy Controls
Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use.
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital

This content was sourced from clinicaltrials.gov

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